Also see: University of St Andrews Researcher Profile
2021
Vasou, A, Nightingale, K, Cetkovská, V, Bamford, CGG, Andrejeva, A, Randall, RE, McLauchlan, J, Weekes, MP, Hughes, DJ. A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling. bioRxiv 2021. 3 June 2021. Read it.
Jones, CE, Tan, WF, Grey, F, Hughes, DJ. Discovering antiviral restriction factors and pathways using genetic screens. Journal of General Virology 2021. 102(5). Read it.
2020
Holthaus, D*, Vasou, A*, Bamford, CGG, Andrejeva, J, Paulus, C, Randall, RE, McLauchlan, J & Hughes, DJ. Direct antiviral activity of IFN-stimulated genes is responsible for resistance to paramyxoviruses in ISG15-deficient cells. Journal of Immunology 2020. 23 Apr 2020, 205(1) 261-271. Read it. * Equal contribution.
Wignall-Fleming, EB, Vasou, A, Young, D, Short, JAL, Hughes, DJ, Goodbourn, S & Randall, RE. Innate intracellular responses restrict he amplification of defective virus genomes of parainfluenza virus type 5. Journal of Virology 2020. 15 Apr 2020 Read it.
Yetming, K, Lupey-Green, L, Biryukov, S, Hughes, DJ, Marendy, E, Miranda, JJ, Sample, J. The BHLF1 locus of Eptein-Barr Virus contributes to viral latency and B-cell immortalization. Journal of Virology 2020. Read it.
2019
Wignall-Fleming EB, Hughes DJ, Vattipally S, Modha S, Goodbourn S, Davison AJ & Randall RE. Analysis of paramyxovirus transcription and replication by high-throughput sequencing. Journal of Virology 2019. 93(17), e00571-19. Read it. *Spotlight article
2018
Manners O, Murphy J, Coleman A, Hughes DJ, Whitehouse A. Contribution of the KSHV and EBV Lytic Cycles to Tumourigenesis. Current Opinions in Virology 2018; 32:60–70. Read it.
2017
Hughes DJ+, Tiede C, Penswick N, Tang AAS, Trinh CH, Mandal U, Zajac KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC+, Whitehouse A+.Generation of specific inhibitors of SUMO1- and SUMO2/3-mediated protein-protein interactions using Affimer (Adhiron) technology. Science Signaling 2017; 10(505). +Corresponding authors. Read it. Datasets.
Tang AAS, Tiede C, Hughes DJ, McPherson MJ, Tomlinson DC. Isolation of isoform-specific binding proteins (Adhirons/Affimers) by phage display using negative selection. Science Signaling 2017; 10(505). Read it.
2016
Wood JJ, Boyne JR, Paulus C, Jackson BR, Nevels MM, Whitehouse A, Hughes DJ. ARID3B: A novel regulator of the Kaposi’s sarcoma-associated herpesvirus lytic cycle. Journal of Virology 2016; 90(20):9543-9555. Read it.
2015
Hughes DJ+, Wood J, Jackson BR, Baquero B, Whitehouse A+. NEDDylation regulates Kaposi’s sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target. PLoS Pathogens 2015; 11(3):e1004771. +Corresponding authors. Read it.
Lui L, Lear Z, Hughes DJ, Wu W, Emmott E, Zhou E, Whitehouse A, Chen H, Hiscox JA. Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus (PRRSV) identifies a cellular target whose disruption allows resistance free antiviral activity. Veterinary Microbiology 2015; 176(1-2):109-119. Read it.
Leeming G, Kipar A, Hughes DJ, Bingle L, Bennett E, Moyo N, Tripp RA, Bigley A, Bingle CD, Sample JT, Stewart JP. Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract. Laboratory Investigation 2015; 95:610-624. Read it.
Munday DC, Wu W, Smith N, Fix J, Noton S, Galloux M, Touzelet O, Armstrong S, Aljabr W, Easton A, Rameix-Welti M-E, Peres de Oliveira A, Simabuco F, Ventura A, Hughes DJ, Barr JN, Fearns R, Digard P, Eleouet J-F, Hiscox JA. Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important co-factors that promote L protein stability and RNA synthesis. Journal of Virology 2015; 89(2):917-930. Read it.
2014
Owen CB, Hughes DJ, Baquero-Perez B, Berndt A, Schumann S, Jackson BR, Whitehouse A. Utilizing proteomics to understand oncogenic herpesviruses. Molecular and Clinical Oncology 2014; DOI: 10.3892/mco2014341. Read it.
2012
Hughes DJ, Marendy EM, Dickerson CA, Yetming KD, Sample CE, Sample JT. Contributions of CTCF and DNA Methyltransferases DNMT1 and DNMT3B to Regulation of Epstein-Barr Virus Latency. Journal of Virology 2012; 86(2):1034-1045. Read it.
Hughes DJ, Kipar A, Leeming GH, Sample JT, Stewart JP. Experimental infection of laboratory-bred bank voles (Myodes glareolus) with Murid Herpesvirus 4. Archives of Virology 2012; DOI. 10.1007/s00705-012-1397-5.
Stevens HC, Cham KS-W, Hughes DJ, Sun R, Sample JT, Bubb VJ, Stewart JP, Quinn JP. CTCF and Sp1 interact with the murine gammaherpesvirus 68 internal repeat elements. Virus Genes 2012; 45(2):265-273. Read it.
Hughes DJ, Dickerson CA, Shaner MS, Sample CE, Sample JT. trans-Repression of Protein Expression Dependent on the Epstein-Barr Virus Promoter Wp During Latency. Journal of Virology 2012; 85(21):11435-47. Read it.
2011
Hughes DJ, Kipar A, Leeming GH, Bennett E, Howarth D, Cummerson J, Papoula-Pereira R, Flanagan BF, Sample JT, Stewart JP. Chemokine Binding Protein M3 of Murine Gammaherpesvirus 68 Modulates the Host Response to Infection in a Natural Host. PLoS Pathogens, 2011; 7(3):e1001321. Read it.
Taylor A, Jackson BR, Noerenberg M, Hughes DJ, Boyne JR, Verow M, Harris M, Whitehouse A. Mutation of a C-terminal Motif Affects KSHV ORF57 RNA Binding, Nuclear Trafficking and Multimerisation. Journal of Virology 2011; 85(15):7881-91. Read it.
Quinn JP, Kipar A, Hughes DJ, Bennett E, Cox H, McLaughlin L, Zimmer A, Hunt SP, Stewart JP. Altered Host Response to Infection In Mice Lacking the Tachykinin 1 Gene and the Receptor For Substance P. Neuropeptides 2011; 45:49-53. Read it.
2010
Hughes DJ, Kipar A, Sample JT, Stewart JP. Pathogenesis of a Model Gammaherpesvirus in a Natural Host. Journal of Virology 2010; 84(8):3949-3961. Read it.
Baird NL, Starkey JL, Hughes DJ, Wills JW. Myristylation and Palmitylation of HSV-1 UL11 Are Not Essential For Its Function. Virology 2010; 397(1):80-88. Read it.
Hughes DJ, Kipar A, Milligan SG, Cunningham C, Sanders M, Quail MA, Rajandream M, Efstathiou S, Bowden RJ, Chastel C, Bennett M, Sample JT, Barrell B, Davison AJ, Stewart JP. Characterization of a Novel Wood Mouse Herpesvirus Related to Murid Herpesvirus 4. Journal of General Virology 2010; 91(4):867-879. Read it.
2009
Reilly SC, Kipar A, Hughes DJ, Quinn JP, Cossins AR, Sneddon LU. Investigation of Van Gogh-like 2 mRNA Regulation and Localisation in Response to Nonciception in the Brain of Adult Common Carp (Cyprinus carpio). Neuroscience Letters 2009; 465(3):290-4.
2008
Sample JT, Marendy EM, Hughes DJ, Sample CE. The Epstein-Barr Virus Genome. In DNA Tumor Viruses. Damania and Pipas (Eds.). Springer 2008; pp. 241-258.
2007
Ehlers B, Kuchler J, Yasmum N, Dural G, Voigt S, Schmidt-Chanasit J, Jakel T, Matuschka F, Richter D, Essbauer S, Hughes DJ, Summers C, Bennett M, Stewart JP, Ulrich RG. Identification of Novel Rodent Herpesviruses Including the First Gammaherpesvirus of Mus musculus. Journal of Virology 2007; 81(15):8091-8100. Read it.
2006
Spencer EM, Chandler KE, Haddley K, Howard MR, Hughes D, Belyaev ND, Coulson JM, Stewart JP, Buckley NJ, Kipar A, Walker MC, Quinn JP. Regulation and Role of REST and REST4 Variants in Modulation of Gene Expression in In Vivo and In Vitro in Epilepsy Models. Neurobiology of Disease 2006; 24(1):41-52.
2005
Stewart JP, Hughes DJ, Roaden L, Ebrahimi B. Murid Herpesvirus 4 as a Model for Gammaherpesvirus Pathogenesis. In SGM Symposium 64: Molecular Pathogenesis of Viral Infections. Digard, Nash and Randall (Eds.). Cambridge University Press 2005; pp.319-341.
2004
Stewart JP, Silvia OJ, Atkin IMD, Hughes DJ, Ebrahimi B, Adler H. In Vivo Function of a Gammaherpesvirus Virion Glycoprotein: Influence on B-Cell Infection and Mononucleosis. Journal of Virology 2004; 78(19):10449–10459.
2021
Vasou, A, Nightingale, K, Cetkovská, V, Bamford, CGG, Andrejeva, A, Randall, RE, McLauchlan, J, Weekes, MP, Hughes, DJ. A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling. bioRxiv 2021. 3 June 2021. Read it.
Jones, CE, Tan, WF, Grey, F, Hughes, DJ. Discovering antiviral restriction factors and pathways using genetic screens. Journal of General Virology 2021. 102(5). Read it.
2020
Holthaus, D*, Vasou, A*, Bamford, CGG, Andrejeva, J, Paulus, C, Randall, RE, McLauchlan, J & Hughes, DJ. Direct antiviral activity of IFN-stimulated genes is responsible for resistance to paramyxoviruses in ISG15-deficient cells. Journal of Immunology 2020. 23 Apr 2020, 205(1) 261-271. Read it. * Equal contribution.
Wignall-Fleming, EB, Vasou, A, Young, D, Short, JAL, Hughes, DJ, Goodbourn, S & Randall, RE. Innate intracellular responses restrict he amplification of defective virus genomes of parainfluenza virus type 5. Journal of Virology 2020. 15 Apr 2020 Read it.
Yetming, K, Lupey-Green, L, Biryukov, S, Hughes, DJ, Marendy, E, Miranda, JJ, Sample, J. The BHLF1 locus of Eptein-Barr Virus contributes to viral latency and B-cell immortalization. Journal of Virology 2020. Read it.
2019
Wignall-Fleming EB, Hughes DJ, Vattipally S, Modha S, Goodbourn S, Davison AJ & Randall RE. Analysis of paramyxovirus transcription and replication by high-throughput sequencing. Journal of Virology 2019. 93(17), e00571-19. Read it. *Spotlight article
2018
Manners O, Murphy J, Coleman A, Hughes DJ, Whitehouse A. Contribution of the KSHV and EBV Lytic Cycles to Tumourigenesis. Current Opinions in Virology 2018; 32:60–70. Read it.
2017
Hughes DJ+, Tiede C, Penswick N, Tang AAS, Trinh CH, Mandal U, Zajac KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC+, Whitehouse A+.Generation of specific inhibitors of SUMO1- and SUMO2/3-mediated protein-protein interactions using Affimer (Adhiron) technology. Science Signaling 2017; 10(505). +Corresponding authors. Read it. Datasets.
Tang AAS, Tiede C, Hughes DJ, McPherson MJ, Tomlinson DC. Isolation of isoform-specific binding proteins (Adhirons/Affimers) by phage display using negative selection. Science Signaling 2017; 10(505). Read it.
2016
Wood JJ, Boyne JR, Paulus C, Jackson BR, Nevels MM, Whitehouse A, Hughes DJ. ARID3B: A novel regulator of the Kaposi’s sarcoma-associated herpesvirus lytic cycle. Journal of Virology 2016; 90(20):9543-9555. Read it.
2015
Hughes DJ+, Wood J, Jackson BR, Baquero B, Whitehouse A+. NEDDylation regulates Kaposi’s sarcoma-associated herpesvirus latency and lytic reactivation and represents a novel anti-KSHV target. PLoS Pathogens 2015; 11(3):e1004771. +Corresponding authors. Read it.
Lui L, Lear Z, Hughes DJ, Wu W, Emmott E, Zhou E, Whitehouse A, Chen H, Hiscox JA. Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus (PRRSV) identifies a cellular target whose disruption allows resistance free antiviral activity. Veterinary Microbiology 2015; 176(1-2):109-119. Read it.
Leeming G, Kipar A, Hughes DJ, Bingle L, Bennett E, Moyo N, Tripp RA, Bigley A, Bingle CD, Sample JT, Stewart JP. Gammaherpesvirus infection modulates the temporal and spatial expression of SCGB1A1 (CCSP) and BPIFA1 (SPLUNC1) in the respiratory tract. Laboratory Investigation 2015; 95:610-624. Read it.
Munday DC, Wu W, Smith N, Fix J, Noton S, Galloux M, Touzelet O, Armstrong S, Aljabr W, Easton A, Rameix-Welti M-E, Peres de Oliveira A, Simabuco F, Ventura A, Hughes DJ, Barr JN, Fearns R, Digard P, Eleouet J-F, Hiscox JA. Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important co-factors that promote L protein stability and RNA synthesis. Journal of Virology 2015; 89(2):917-930. Read it.
2014
Owen CB, Hughes DJ, Baquero-Perez B, Berndt A, Schumann S, Jackson BR, Whitehouse A. Utilizing proteomics to understand oncogenic herpesviruses. Molecular and Clinical Oncology 2014; DOI: 10.3892/mco2014341. Read it.
2012
Hughes DJ, Marendy EM, Dickerson CA, Yetming KD, Sample CE, Sample JT. Contributions of CTCF and DNA Methyltransferases DNMT1 and DNMT3B to Regulation of Epstein-Barr Virus Latency. Journal of Virology 2012; 86(2):1034-1045. Read it.
Hughes DJ, Kipar A, Leeming GH, Sample JT, Stewart JP. Experimental infection of laboratory-bred bank voles (Myodes glareolus) with Murid Herpesvirus 4. Archives of Virology 2012; DOI. 10.1007/s00705-012-1397-5.
Stevens HC, Cham KS-W, Hughes DJ, Sun R, Sample JT, Bubb VJ, Stewart JP, Quinn JP. CTCF and Sp1 interact with the murine gammaherpesvirus 68 internal repeat elements. Virus Genes 2012; 45(2):265-273. Read it.
Hughes DJ, Dickerson CA, Shaner MS, Sample CE, Sample JT. trans-Repression of Protein Expression Dependent on the Epstein-Barr Virus Promoter Wp During Latency. Journal of Virology 2012; 85(21):11435-47. Read it.
2011
Hughes DJ, Kipar A, Leeming GH, Bennett E, Howarth D, Cummerson J, Papoula-Pereira R, Flanagan BF, Sample JT, Stewart JP. Chemokine Binding Protein M3 of Murine Gammaherpesvirus 68 Modulates the Host Response to Infection in a Natural Host. PLoS Pathogens, 2011; 7(3):e1001321. Read it.
Taylor A, Jackson BR, Noerenberg M, Hughes DJ, Boyne JR, Verow M, Harris M, Whitehouse A. Mutation of a C-terminal Motif Affects KSHV ORF57 RNA Binding, Nuclear Trafficking and Multimerisation. Journal of Virology 2011; 85(15):7881-91. Read it.
Quinn JP, Kipar A, Hughes DJ, Bennett E, Cox H, McLaughlin L, Zimmer A, Hunt SP, Stewart JP. Altered Host Response to Infection In Mice Lacking the Tachykinin 1 Gene and the Receptor For Substance P. Neuropeptides 2011; 45:49-53. Read it.
2010
Hughes DJ, Kipar A, Sample JT, Stewart JP. Pathogenesis of a Model Gammaherpesvirus in a Natural Host. Journal of Virology 2010; 84(8):3949-3961. Read it.
Baird NL, Starkey JL, Hughes DJ, Wills JW. Myristylation and Palmitylation of HSV-1 UL11 Are Not Essential For Its Function. Virology 2010; 397(1):80-88. Read it.
Hughes DJ, Kipar A, Milligan SG, Cunningham C, Sanders M, Quail MA, Rajandream M, Efstathiou S, Bowden RJ, Chastel C, Bennett M, Sample JT, Barrell B, Davison AJ, Stewart JP. Characterization of a Novel Wood Mouse Herpesvirus Related to Murid Herpesvirus 4. Journal of General Virology 2010; 91(4):867-879. Read it.
2009
Reilly SC, Kipar A, Hughes DJ, Quinn JP, Cossins AR, Sneddon LU. Investigation of Van Gogh-like 2 mRNA Regulation and Localisation in Response to Nonciception in the Brain of Adult Common Carp (Cyprinus carpio). Neuroscience Letters 2009; 465(3):290-4.
2008
Sample JT, Marendy EM, Hughes DJ, Sample CE. The Epstein-Barr Virus Genome. In DNA Tumor Viruses. Damania and Pipas (Eds.). Springer 2008; pp. 241-258.
2007
Ehlers B, Kuchler J, Yasmum N, Dural G, Voigt S, Schmidt-Chanasit J, Jakel T, Matuschka F, Richter D, Essbauer S, Hughes DJ, Summers C, Bennett M, Stewart JP, Ulrich RG. Identification of Novel Rodent Herpesviruses Including the First Gammaherpesvirus of Mus musculus. Journal of Virology 2007; 81(15):8091-8100. Read it.
2006
Spencer EM, Chandler KE, Haddley K, Howard MR, Hughes D, Belyaev ND, Coulson JM, Stewart JP, Buckley NJ, Kipar A, Walker MC, Quinn JP. Regulation and Role of REST and REST4 Variants in Modulation of Gene Expression in In Vivo and In Vitro in Epilepsy Models. Neurobiology of Disease 2006; 24(1):41-52.
2005
Stewart JP, Hughes DJ, Roaden L, Ebrahimi B. Murid Herpesvirus 4 as a Model for Gammaherpesvirus Pathogenesis. In SGM Symposium 64: Molecular Pathogenesis of Viral Infections. Digard, Nash and Randall (Eds.). Cambridge University Press 2005; pp.319-341.
2004
Stewart JP, Silvia OJ, Atkin IMD, Hughes DJ, Ebrahimi B, Adler H. In Vivo Function of a Gammaherpesvirus Virion Glycoprotein: Influence on B-Cell Infection and Mononucleosis. Journal of Virology 2004; 78(19):10449–10459.