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Grant Success - AMS6/2/2018 We’re really excited to announce that we have just had our Academy of Medical Sciences Springboard grant funded and we will soon be recruiting a postdoc to join the team. Informal inquiries can be made by email – [email protected]
Lay summary of the project: As our first line of defence against viruses our cells produce factors aimed at fighting the infection. This response, known as the innate immune response, involves hundreds of proteins that work in concert to directly attack the virus and to self-regulate the magnitude of the response; the latter is essential as a dysregulated response can lead to debilitating and often life-threatening autoimmune diseases. Our research focuses on the involvement of a protein called ISG15 in this response. Importantly, people have been identified who cannot produce ISG15 and this caused diseases collectively known as autoinflammatory interferonopathies, characterised by increased susceptibility to infections and adverse reactions to vaccination. Furthermore, it tells us that ISG15 plays a critical role in the proper regulation of our immune response. This work is aimed at understanding the molecular mechanisms that ISG15 regulates in order to bring about normal function of our innate immune response. Together, this programme of research will provide important insights into the physiological role of ISG15 during the immune response which has implications for our fundamental understanding of innate immunity,health and disease.
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