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Two new papers published14/11/2017 We are pleased to announce that the lab has published two new research articles in Science Signalling. The first is work describing an innovative approach to investigating protein-protein interactions that are dependent on SUMOylation. Critically, we developed ways of discriminating between the highly related protein isoforms of SUMO. The second is an accompanying ‘Protocol’ that describes our approach.
Citations: Hughes DJ+, Tiede C, Penswick N, Tang AAS, Trinh CH, Mandal U, Zajac KZ, Gaule T, Howell G, Edwards TA, Duan J, Feyfant E, McPherson MJ, Tomlinson DC+, Whitehouse A+.Generation of specific inhibitors of SUMO1- and SUMO2/3-mediated protein-protein interactions using Affimer (Adhiron) technology. Science Signaling 2017; 10(505). +Corresponding authors. Read it. Tang AAS, Tiede C, Hughes DJ, McPherson MJ, Tomlinson DC. Isolation of isoform-specific binding proteins (Adhirons/Affimers) by phage display using negative selection. Science Signaling 2017; 10(505). Read it.
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